Each farm has a small piece of land where items, buildings, animals, or plots can’t be placed. It is usually located at the top right corner for most farms with the exception of Fields of El Dorado and Haunted Hollow.
It might seem like the unusable space is wasted, but actually that small spot is marked by default for one of the buildable already present in the farm. This is why this spot is not usable.
The spot in most farms

The spot in Fields of El Dorado

The spot in Haunted Hollow

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FarmVille 2: Country Escape Game GUIDE
哈利波特:巫師聯盟